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目的:探讨腹腔镜胆囊切除术治疗急性化脓性胆囊炎的疗效及对患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)及肝功能的影响。方法:选择2014年9月至2016年9月我院接诊的92例急性化脓性胆囊炎患者,随机分为观察组(n=46)和对照组(n=46),对照组使用传统开腹式胆囊切除术,观察组使用腹腔镜下胆囊切除术。观察并比较两组患者的术中出血量、术后引流量、手术时间、术后排气时间及住院时间,治疗前后丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、超氧化物歧化酶(SOD)及丙二醛(MDA)水平,以及术后并发症的发生情况。结果:观察组术中出血量、术后引流量少于对照组,手术时间、术后排气时间、排便时间、住院时间均比对照组短(P<0.05);手术后,观察组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)水平均比对照组低(P<0.05);观察组超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)水平低于对照组(P<0.05);观察组术后并发症总发生率低于对照组(P<0.05)。结论:腹腔镜胆囊切除术治疗急性化脓性胆囊炎的效果显著,对患者肝功能损伤较小,术后并发症少,值得临床应用推广。
Objective: To investigate the curative effect of laparoscopic cholecystectomy on acute suppurative cholecystitis and its effect on serum superoxide dismutase (SOD), malondialdehyde (MDA) and liver function. Methods: A total of 92 patients with acute suppurative cholecystitis admitted to our hospital from September 2014 to September 2016 were randomly divided into observation group (n = 46) and control group (n = 46) Abdominal cholecystectomy was performed in the observation group using laparoscopic cholecystectomy. The blood loss, postoperative drainage volume, operation time, postoperative exhaust time and hospital stay were observed and compared between the two groups. Before and after treatment, the levels of ALT, AST ), Total bilirubin (TBIL), superoxide dismutase (SOD) and malondialdehyde (MDA) levels, as well as the incidence of postoperative complications. Results: The intraoperative blood loss and postoperative drainage were less in the observation group than those in the control group. The operation time, postoperative exhaust time, defecation time and hospital stay were shorter than those in the control group (P <0.05). After the operation, The levels of ALT, AST and TBIL were lower than those in the control group (P <0.05). The levels of superoxide dismutase (SOD) in the observation group were high The MDA level in the control group was lower than that in the control group (P <0.05). The incidence of postoperative complications in the observation group was lower than that in the control group (P <0.05). Conclusion: The effect of laparoscopic cholecystectomy in the treatment of acute suppurative cholecystitis is remarkable. It has less damage to liver function and less postoperative complications, which is worth to be popularized in clinical application.