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目的观察双环醇联合熊去氧胆酸(UDCA)治疗药物性肝损伤(DILI)的疗效。方法将119例药物性肝损伤患者随机分为3组,A组38例,给予传统治疗;B组42例,给予传统治疗+UDCA;C组39例,给予传统治疗+UDCA+双环醇;3组患者治疗观察4周。结果 A组患者肝功能指标好转,血清肝纤维化指标下降,但与治疗前比较差异无统计学意义(P>0.05)。B组患者肝功能指标好转,与治疗前比较差异有统计学意义(P<0.01),血清肝纤维化指标和血清球蛋白水平与治疗前比较差异无统计学意义(P>0.05)。C组患者肝功能指标、血清肝纤维化指标和血清球蛋白水平下降程度均优于A组和B组(P<0.01)。结论药物性肝损伤患者,给予双环醇治疗,同时应用熊去氧胆酸治疗可有效改善患者肝功能及肝纤维化指标。
Objective To observe the efficacy of bicyclic alcohol combined with ursodeoxycholic acid (UDCA) in the treatment of drug-induced liver injury (DILI). Methods A total of 119 patients with drug-induced liver injury were randomly divided into three groups: group A (38 cases) given conventional treatment; group B (42 cases) received conventional therapy plus UDCA; group C (39 cases) received conventional therapy plus UDCA + Patient treatment for 4 weeks. Results A group of patients with liver function improved, serum hepatic fibrosis index decreased, but compared with before treatment was no significant difference (P> 0.05). The indexes of liver function improved in group B, with statistical significance (P <0.01). There was no significant difference in serum level of hepatic fibrosis and serum globulin between before and after treatment (P> 0.05). The liver function indexes, serum hepatic fibrosis indexes and serum globulin levels in group C were significantly lower than those in group A and group B (P <0.01). Conclusion Patients with drug-induced liver injury, given bicyclol treatment, while the application of ursodeoxycholic acid can effectively improve liver function and liver fibrosis in patients with indicators.