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Ⅰ型糖尿病及实验性糖尿病模型均证实存在肾小球高滤过及肾小球肥大,但有关Ⅱ型糖尿病(NIDDM)的情况各家报道不一。常用的内生肌酐清除率(Ccr)往往不能准确反映肾小球滤过率(GFR);且NIDDM患者多肥胖,使用实际体表面积易低估GFR。鉴于此,作者应用稳定的菊粉输注技术测定GFR,并用非脂肪体重(lean body mass)以校正。病人和方法新诊断的NIDDM患者16例(男13、女3例),诊断依据国际糖尿病资料组的标准。诊断时平均空腹血糖160(135～
Type 1 diabetes mellitus and experimental diabetes mellitus confirmed the presence of glomerular hyperfiltration and glomerular hypertrophy, but there are various reports about type 2 diabetes (NIDDM). Commonly used endogenous creatinine clearance (Ccr) often can not accurately reflect the glomerular filtration rate (GFR); and more obese NIDDM patients, the use of the actual body surface area is easy to underestimate GFR. In view of this, the authors applied a stable inulin infusion technique to determine GFR and corrected with lean body mass. Patients and Methods 16 newly diagnosed NIDDM patients (13 males and 3 females) were diagnosed based on the International Diabetes Data Section. The average fasting blood glucose at diagnosis 160 (135 ~