论文部分内容阅读
为了寻找新型高效低毒的农药先导化合物,通过N-吡啶基吡唑肟与2-氯-5-氯甲基吡啶的缩合反应,合成了一系列含吡啶环取代的吡唑肟醚类化合物.目标化合物的结构均经1H NMR,13C NMR和元素分析确证.初步生物活性试验结果表明,部分化合物具有一定的杀菌、杀虫和植物生长调节活性.如化合物5c在浓度为50μg/mL时对番茄早疫的抑制率为61.4%;化合物5j在浓度为50μg/mL时对花生褐斑的抑制率为60.2%;化合物5i在浓度为500μg/mL时对蚜虫表现出50.3%的杀死率;化合物5f在浓度为10μg/mL时对黄瓜子叶生根表现出71.0%的促进生长作用.
In order to find a new pesticide lead compound with high toxicity and low toxicity, a series of pyrazole oxime ethers substituted with pyridine ring were synthesized by the condensation of N-pyridyl pyrazole oxime with 2-chloro-5-chloromethylpyridine. The structures of the target compounds were confirmed by 1H NMR, 13C NMR and elemental analysis. The preliminary bioassay results showed that some of the compounds had some bactericidal, insecticidal and plant growth regulating activities. For example, when compound 5c was used at a concentration of 50μg / mL, The rate of inhibition against early blight was 61.4%. The inhibitory rate of compound 5j against peanut plaque was 60.2% at the concentration of 50μg / mL. Compound 5i showed a 50.3% killing rate to aphid at the concentration of 500μg / mL. Compound 5i 5f showed 71.0% growth promoting effect on cucumber cotyledon rooting at the concentration of 10μg / mL.