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以放射免疫测定法检测尿白蛋白，筛选出糖尿病肾病４７例（其中早期４０例，临床期７例），随机分成两组，采用自身对照试验比较山莨菪碱与卡托普利对糖尿病肾病的影响。结果显示：山莨菪碱和卡托普利治疗４周后，患者有效肾血浆流量上升，肾小球滤过分数下降，而肌酐清除率无明显变化；尿白蛋白平均下降４９ｍｇ／ｄ（Ｐ＜０．０１）与５７ｍｇ／ｄ（Ｐ＜０．００５）：这表明山莨菪碱具有与卡托普利类似的降低尿蛋白和改善肾功能的作用。
Urinary albumin was detected by radioimmunoassay, and 47 cases of diabetic nephropathy were screened out (40 in early stage and 7 in clinical stage), and were randomly divided into two groups. The self-control test was used to compare the effects of anisodamine and captopril on diabetic nephropathy influences. The results showed that after 4 weeks treatment with anisodamine and captopril, the effective renal plasma flow increased, the glomerular filtration fraction decreased, but the creatinine clearance rate had no obvious change; the urinary albumin decreased by 49 mg / d on average (P < 0.01) and 57 mg / d (P <0.005): This indicates that anisodamine has a similar effect to captopril in reducing urinary protein and improving renal function.