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对３０例接受胰岛移植后服用雷公藤多甙（ＴⅡ）的Ⅰ型糖尿病患者（ＴⅡ组）与２４例胰岛移植后未应用任何免疫抑制剂的患者（对照组），分别在移植前及后１５天、１个月、６个月、１年检测外周血Ｔ细胞亚群、血清Ｃ肽，并与２０例健康人作对照。结果：移植前两组患者ＣＤ２、ＣＤ４均明显低于正常（Ｐ＜０．０１），ＣＤ４／ＣＤ８比值在１．２～２．０之间，移植后两组患者ＣＤ２、ＣＤ４均升高，ＴⅡ组接近正常（Ｐ＞０．０５），对照组ＣＤ４／ＣＤ８比值＞２．０。ＴⅡ组１９例胰岛素用量平均减少８４．２％，其中２例停用胰岛素；血清Ｃ肽水平峰值达３．２４±１．２ｎｇ／ｍｌ。对照组移植后６个月内与前者相仿（Ｐ＞０．０５），以后逐渐加大胰岛素用量，血清Ｃ肽亦下降，１年时接近术前状态（Ｐ＞０．０５）。提示ＴⅡ对胰岛移植具有免疫抑制功能，可延长移植物在受体内存活时间。
Thirty patients with type I diabetes (TII) and twenty-four patients without any immunosuppressive agent after islet transplantation (control group) received isoflurane (TII) after islet transplantation, Day, 1 month, 6 months and 1 year to detect peripheral T cell subsets and serum C-peptide, and compared with 20 healthy people. Results: Before transplantation, CD2 and CD4 were significantly lower than normal (P <0.01), and CD4 / CD8 ratio was between 1.2 and 2.0. CD2 and CD4 in both groups after transplantation increased, T Ⅱ group was close to normal (P> 0.05), the control group CD4 / CD8 ratio> 2.0. In the TII group, the insulin dosage decreased by 84.2% on average in 19 patients, of which 2 patients stopped using insulin. The peak value of serum C peptide reached 3.24 ± 1.2ng / ml. The control group within 6 months after transplantation with the former similar (P> 0.05), then gradually increase the amount of insulin, serum C-peptide also decreased, 1 year close to the preoperative state (P> 0.05). Tip T Ⅱ islet transplantation has immunosuppressive function, can extend the graft survival time in the recipient.