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目的研究我国西北汉族人群基质金属蛋白酶(matrixmetalloproteinase1,MMP1)基因-1607(1G→2G)多态与肺癌发生风险的关系。方法应用聚合酶链反应限制性片段长度多态性分析的方法,检测了150例肺癌患者和200名正常对照者MMP11G→2G多态的基因型,比较不同基因型与肺癌发生风险的关系。结果肺癌组2G/2G基因型频率要高于对照组(χ2=5.896,P<0.05),2G/2G基因型者患肺癌的风险是1G/2G和1G/1G基因型的1.77倍(OR=1.77;95%CI:1.12～2.91)。吸烟者中2G/2G基因型发生肺癌的风险是1G/2G和1G/1G基因型的3.20倍(OR=3.20;95%CI:1.50～6.82)。结论我国西北汉族人群MMP1基因-1607(1G→2G)多态性与肺癌易感性有关,2G/2G基因型可以增加肺癌发生风险。
Objective To investigate the relationship between the gene polymorphism of matrix metalloproteinase 1 (MMP-1) -1607 (1G → 2G) and the risk of lung cancer in northwestern Han nationality in China. Methods The genotypes of MMP11G → 2G polymorphism in 150 lung cancer patients and 200 normal controls were detected by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The relationship between different genotypes and the risk of lung cancer was compared. Results The frequency of 2G / 2G genotype in lung cancer group was higher than that in control group (χ2 = 5.896, P <0.05). The risk of lung cancer in 2G / 2G genotype was 1.77 times of that in 1G / 2G and 1G / 1G genotypes (OR = 1.77; 95% CI: 1.12 ~ 2.91). The risk of lung cancer in 2G / 2G genotypes among smokers was 3.20 times higher than that of 1G / 2G and 1G / 1G genotypes (OR = 3.20; 95% CI: 1.50-6.82). Conclusion The polymorphism of -1607 (1G → 2G) of MMP1 gene in Northwest Han population is related to the susceptibility to lung cancer. The 2G / 2G genotype may increase the risk of lung cancer.