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目的研究900MHzGSM微波辐射对二甲基苯并蒽(DMBA)诱发的SD大鼠乳腺癌是否有促进作用。方法500只大鼠按体重分为5个实验组,并按35mg/kg体重1次性灌胃给予DMBA。其中,1组为不给予辐照的空白对照组,其余4组的900MHzGSM微波辐照剂量为双盲,比吸收率值分别为:0(假辐照)、0.44、1.33和4.00W/kg。微波辐照开始于给予DMBA后第2天,持续26周,每周辐照5次,每次持续4h,在辐照全部结束后第3至第7天中处死动物,进行病理学和肿瘤发生学研究。结果假辐照组大鼠乳腺癌的发生率为37%(37/100);辐照剂量分别为0.44、1.33和4.00W/kg的各组大鼠乳腺癌发生率分别为25%(25/100)、34%(34/99)和38%(38/100),与假辐照组比较,均差异无统计学意义。病理组织形态学观察可见,该模型的乳腺肿瘤有恶性与良性两类,恶性肿瘤有乳腺腺癌和鳞状细胞癌,良性肿瘤有腺瘤、纤维腺瘤和乳腺囊肿。有时几种病理形态可同时出现在1个个体中,其组织病理表现呈多样性。结论在本实验条件下,900MHz的GSM微波辐射对DMBA诱发大鼠乳腺癌的发生无促进作用。
Objective To investigate whether 900MHzGSM microwave irradiation can promote the growth of SD rat breast cancer induced by dimethylbenzanthracene (DMBA). Methods 500 rats were divided into five experimental groups according to their body weight. DMBA was given intragastrically once a day by 35 mg / kg body weight. One group was blank control group without irradiation, the other four groups 900MHzGSM microwave dose was double-blind, specific absorption values were 0 (sham irradiation), 0.44,1.33 and 4.00W / kg. The microwave irradiation began on the second day after administration of DMBA for 26 weeks, five times a week for 4 hours each, and the animals were sacrificed on the third to seventh days after the irradiation was completed, for pathological and tumorigenic studies . Results The incidence of breast cancer in the sham irradiation group was 37% (37/100). The incidences of breast cancer in the irradiated group were 25% (25/45) for the groups of 0.44, 1.33 and 4.00 W / kg, respectively 100), 34% (34/99) and 38% (38/100), respectively. There was no significant difference between the sham irradiation group and the sham irradiation group. Histopathological examination shows that the model of breast cancer are malignant and benign, malignant breast adenocarcinoma and squamous cell carcinoma, benign adenoma, fibroadenoma and breast cyst. Sometimes several pathological forms can appear in an individual at the same time, the histopathological manifestations showed diversity. Conclusion Under the experimental conditions, 900MHz GSM microwave radiation has no effect on the development of DMBA-induced rat breast cancer.