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目的研究急慢性乙型肝炎uPA和uPAR的表达,探讨肝炎发病时血液纤溶的变化及意义。方法应用酶联免疫吸附试验(ELISA)测定血浆uPA和uPAR的水平。结果急慢性乙型肝炎血浆uPA和uPAR水平与对照组比较均有意义地高于对照组(P<0.01);慢性乙型肝炎重度组血浆uPA和uPAR水平显著高于急性乙型肝炎组(P<0.05),亦显著高于慢性乙型肝炎中轻度组(P<0.05和P<0.01);急性乙型肝炎血浆中uPAR水平显著高于慢性乙型肝炎中轻度组(P<0.01);乙型肝炎急性期血浆中uPA和uPAR水平显著升高,恢复期明显回落(P<0.05和P<0.01),但仍明显高于正常对照组(P<0.01);急慢性乙型肝炎血浆中uPAR水平与凝血酶原时间(PT)(r=0.605,P<0.01)和国际标准化比率INR(r=0.603,P<0.01)、胆红素(TB)(r=0.649P<0.01)呈正相关。结论急慢性乙型肝炎uPA和uPAR水平的升高,与炎症的严重程度有关,与肝细胞损伤程度有关,是肝炎发病时血液凝血和纤溶系统失衡的重要原因之一。
Objective To study the expression of uPA and uPAR in acute and chronic hepatitis B and to explore the changes and significance of blood fibrinolysis in the pathogenesis of hepatitis. Methods Serum levels of uPA and uPAR were measured by enzyme-linked immunosorbent assay (ELISA). Results The levels of plasma uPA and uPAR in acute and chronic hepatitis B patients were significantly higher than those in control group (P <0.01). The levels of uPA and uPAR in severe chronic hepatitis B patients were significantly higher than those in acute hepatitis B patients <0.05), but also significantly higher than those in mild chronic hepatitis B (P <0.05 and P <0.01). The levels of uPAR in patients with acute hepatitis B were significantly higher than those in patients with mild hepatitis B (P <0.01) ; The level of uPA and uPAR in the acute phase of hepatitis B were significantly increased, the recovery was significantly decreased (P <0.05 and P <0.01), but still significantly higher than the normal control group (P <0.01); acute and chronic hepatitis B plasma (R = 0.605, P <0.01) and international normalized ratio of INR (r = 0.603, P <0.01) and bilirubin (TB) Related. Conclusions The level of uPA and uPAR in acute and chronic hepatitis B is related to the severity of inflammation and the degree of hepatocyte injury. It is one of the important reasons for the imbalance of blood coagulation and fibrinolysis in the onset of hepatitis.