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细菌脂多糖 (LPS)可激活巨噬细胞、内皮细胞等引起一些炎症介质的释放 ,最终可导致机体的损伤甚至休克死亡。在这一过程中LPS如何被机体细胞识别并启动细胞反应已引起高度重视。十几年来研究已明确LBP CD14、CD11 CD18可使LPS解聚并被运送和结合到细胞表面 ,但是这些分子缺乏信号转导的功能。近二三年发现了一种功能性的LPS跨膜受体———Toll样受体家族。Toll样受体被认为是其它LPS受体的协同受体或接头受体 (adaptorreceptor) ,正是这种受体直接将LPS的刺激信号向细胞内传递 ,其胞浆区具有与IL 1受体同源的结构 ,其作用涉及炎症因子主要是细胞因子级联反应中的基因激活及反应基因的调节
Bacterial lipopolysaccharide (LPS) can activate macrophages, endothelial cells and other release of some inflammatory mediators, and ultimately can lead to body damage and even death in shock. In the process how LPS is recognized by the body cells and start the cellular response has drawn great attention. It has been known for more than a decade that LBP CD14, CD11 CD18, depolymerize LPS and are transported and bound to the cell surface, but these molecules lack the function of signal transduction. In the past two or three years, a functional LPS transmembrane receptor was discovered - the Toll-like receptor family. Toll-like receptors are considered as co-receptors or adapter receptors for other LPS receptors. It is this receptor that directly transmits the stimulatory signals of LPS into cells, Homology of the structure, its role involves the inflammatory cytokines mainly cascade reaction gene activation and response gene regulation