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最近,来自美国加州大学旧金山分校的研究人员发现在多种癌症类型中扮演抑制因子角色的PTEN并非总是发挥抗癌作用,该研究发现PTEN分子能够促进前体B细胞发生癌转化,因此靶向清除PTEN可能是治疗前体B细胞急性淋巴细胞白血病的一种新策略。许多研究表明PTEN是PI3K-AKT信号途径的一个负调控因子,也是一种强力的肿瘤抑制因子,许多癌症类型中都存在PTEN突变,PTEN
Recently, researchers from the University of California, San Francisco, discovered that PTEN acting as a suppressor in a variety of cancer types does not always exert its anti-cancer effect. The study found that PTEN molecules promote the conversion of precursor B cells into cancerous cells and therefore target Removal of PTEN may be a novel strategy for the treatment of B cell acute lymphoblastic leukemia. Many studies have shown that PTEN is a negative regulator of the PI3K-AKT signaling pathway and a potent tumor suppressor, PTEN mutations are present in many types of cancer and PTEN