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为了解ＧＢ病毒Ｃ（ＧＢＶ－Ｃ）感染与肝细胞癌（下称肝癌）之间可能的相关性，采用一步法逆转录聚合酶链反应（ＲＴ－ＰＣＲ）对１２４ 例肝癌患者进行了ＧＢＶ－ＣＲＮＡ 检测。结果：ＧＢＶ－ＣＲＮＡ 总检出率高达２６．６％ （３３／１２４），３３ 例ＧＢＶ－ＣＲＮＡ 检出阳性者中，９０．９％ 合并有ＨＢＶ、ＨＣＶ感染；３３ 例非Ｂ非Ｃ型肝癌中，ＧＢＶ－ＣＲＮＡ检出率为９．１％ （３／３３）。３３ 例ＧＢＶ－Ｃ感染阳性肝癌患者中，９０．０％ （３０／３３）有既往输血史，高于ＧＢＶ－Ｃ感染阴性组（４８／９１）。上述结果提示，我国肝癌患者中ＧＢＶ－Ｃ感染的检出率高于美、欧、日等地同类患者的检出率，其在肝细胞癌及输血后肝炎发生中的病因学意义值得注意。
To understand the possible correlation between GB virus C (GBV-C) infection and hepatocellular carcinoma (hereinafter referred to as hepatocellular carcinoma), one-step reverse transcription polymerase chain reaction (RT-PCR) was performed on 124 patients with liver cancer who underwent GBV- CRNA detection. Results: The total detection rate of GBV-CRNA was as high as 26.6% (33/124). Among the 33 cases with positive GBV-CRNA detection, 90.9% had HBV and HCV infection; 33 cases were non-B non-C type liver cancer Among them, the detection rate of GBV-CRNA was 9.1% (3/33). Of the 33 patients with GBV-C positive liver cancer, 90.0% (30/33) had a prior history of blood transfusion, which was higher than that of the GBV-C negative group (48/91). The above results suggest that the detection rate of GBV-C infection in liver cancer patients in China is higher than that of similar patients in the United States, Europe, and Japan, and its etiological significance in hepatocellular carcinoma and post-transfusion hepatitis is worth noting.