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采用１２５Ｉ标记大豆皂甙，观察了腹腔注射放射性示踪大豆皂甙在大鼠体内和脑内的分布。结果表明：大鼠腹腔内注入放射性大豆皂甙３０ｍｉｎ后，脑和外周组织器官中浓度达到高峰，其中含量较高的组织是脑和肾上腺，在脑中含量最高的区域是下丘脑。证明了外周给予大豆皂甙可以通过血脑屏障进入脑组织，并支持大豆皂甙作用于下丘脑、参与中枢心血管调节的观点；还发现大豆皂甙对肾上腺有很高的亲合性，很可能同时具有外周心血管调节作用。
125I-labeled soybean saponin was used to observe the distribution of radiotracer soy saponin injected intraperitoneally in rats and in the brain. The results showed that rats in the intraperitoneal injection of radioactive soyasaponins 30min, the brain and peripheral tissues in the concentration reached a peak, in which the higher content of the tissue is the brain and adrenal gland, the highest content in the brain is the hypothalamus. It has been proved that soya saponin introduced from the periphery can enter the brain tissue through the blood-brain barrier, and supports the view that soybean saponin acts on the hypothalamus and participates in the central cardiovascular regulation; it has also been found that soybean saponin has high affinity to the adrenal gland, and it is likely to have both Peripheral cardiovascular regulation.