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目的 建立β－淀粉样肽（β－ＡＰ）致大鼠Ａｌｚｈｅｉｍ ｅｒ病（ＡＤ）模型。并对大鼠海马内单胺类神经递质变化进行研究。方法 分别在两组大鼠海马内注射β－ＡＰ和生理盐水，然后用三等分迷宫测定大鼠的学习、记忆功能。迷宫实验结束后迅速处死大鼠，取出海马测定其中单胺类递质代谢产物的含量。结果 海马内注射β－ＡＰ的大鼠的学习、记忆功能出现明显障碍，其海马内的３－甲基－４－羟基苯乙二醇（ＭＨＰＧ）和５－羟吲哚乙酸（５－ＨＩＡＡ）水平明显下降，高香草酸（ＨＶＡ）水平无显著改变。结论 β－ＡＰ致大鼠ＡＤ模型是一种新的成功的ＡＤ动物模型。
Objective To establish a rat model of Alzheimer disease (AD) induced by β-amyloid peptide (β-AP). The changes of monoamine neurotransmitters in the hippocampus of rats were also studied. Methods The β-AP and saline were injected into the hippocampus of rats in each group, and then the learning and memory function of the rats was measured by using the three-parted maze. Rats were sacrificed immediately after the maze test, and the contents of monoamine metabolites in the hippocampus were determined. Results The hippocampal injections of β-AP significantly impaired the learning and memory function of 3-methyl-4-hydroxyphenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA) The level decreased obviously, there was no significant change in HVA level. Conclusion The β-AP-induced AD model is a new and successful AD animal model.