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十二指肠反流具有重要的病理生理意义,但对其机制很少了解。正常人十二指肠内容物在空腹和餐后散在地反流入胃。在胃溃疡、食道炎和胆石性消化不良患者反流增加。实验证明十二指肠中的胆汁酸、胰酶反流入胃能损伤胃和食道粘膜。对反流机制在生理和病理生理上的重要性则了解很少,但有两个前提似乎有根据:第一,十二指肠的收缩性活动是十二指肠内容物逆向移动的推进力;第二,为了这些物质能进入胃,幽门必须开放,或至少部分开放。在空腹时胃肠蠕动是由交替循环的活动与静止状态组成。前者的特征为蠕动从胃至回肠的远端传播,且伴有胃、胰和胆系分泌的增加。这
Duodenal reflux has important pathophysiological significance, but its mechanism is poorly understood. Normal duodenal contents in the fasting and postprandial backwash back to the stomach. Reflux in patients with gastric ulcer, esophagitis and gallstone dyspepsia increased. Experiments show that the bile acid in the duodenum, pancreatin reflux into the stomach can damage the stomach and esophageal mucosa. Little is known about the physiological and pathophysiological importance of the regurgitant mechanism, but there are two premises from which there seem to be a rationale: First, the contractile activity of the duodenum is the propulsion of the reverse movement of the duodenal contents Second, in order for these substances to enter the stomach, the pylorus must be open, or at least partially open. Gastrointestinal motility in fasting is composed of alternating cycles of activity and quiescence. The former is characterized by the spread of peristalsis from the stomach to the distal ileum with an increased secretion of stomach, pancreas and biliary tract. This