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在美国,胆囊疾患是一种很常见的疾病,占主要住院病种的第5位,每年约有100万例胆囊炎新病例需要治疗。胆囊切除术可能是第2种最常做的手术,而且每年因胆道手术死亡的病人最少有3,000例。胆囊和胆道疾患常与胆固醇结石有关,这种结石是由于胆汁内的胆固醇过度饱和,变成“致结石性胆汁”(litho-genic bile)所造成的。胆汁含水85～95%,胆固醇通常不溶于胆汁。但胆固醇可借助含有胆酸和磷脂的微胶粒溶于胆汁之中。胆汁的胆固醇过饱和反映在
Gallbladder disease is a common disease in the United States, which ranks number 5 in major inpatient conditions, and about 1 million new cases of cholecystitis require treatment each year. Cholecystectomy may be the second most common procedure, with a minimum of 3,000 deaths per year due to biliary surgery. Gallbladder and biliary disorders are often associated with cholesterol stones, which are caused by over-saturation of cholesterol in bile into “litho-genic bile.” Cholesterol 85% to 95%, cholesterol is usually insoluble in bile. But cholesterol can be dissolved in bile with the help of micelles containing cholic acid and phospholipids. Cholesterol supersaturation reflected in the