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阵发性房性心律失常(阵发性房性心动过速、心房扑动及心房颤动),临床较常见,呈反复、交替、频繁发作。房性心律失常不仅抑制窦房结自律性,导致窦房结功能障碍,还可使心房发生电重塑及收缩功能障碍。这些结果反过来又促进快速性房性心律失常发作,形成恶性循环。多数病人最终演变成永久性房颤,使心功能明显减退,并可并发血栓栓塞。抗心律失常药对此类心律失常疗效较差,且长期服用存在严重不良反应及致心律失常危险。为防治此类心律失常,1990年Daubert等首先提
Paroxysmal atrial arrhythmia (paroxysmal atrial tachycardia, atrial flutter and atrial fibrillation), clinical more common, was repeated, alternating, frequent attacks. Atrial arrhythmias not only inhibit sinus node self-regulation, leading to sinus node dysfunction, but also make the atrial electrical remodeling and systolic dysfunction. These results in turn promote the onset of tachyarrhythmia, a vicious circle. Most patients eventually evolved into permanent atrial fibrillation, so that heart function decreased significantly, and may be complicated by thromboembolism. Antiarrhythmic drugs have poor efficacy on such arrhythmias and have serious adverse effects and risk of arrhythmia for long-term use. In order to prevent such arrhythmias, Daubert first mentioned in 1990