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研究大黄对增生性肾小球肾炎大鼠肾小球细胞外基质主要成分———纤维连接素的影响。方法：运用大鼠肾毒血清性肾炎作为增生性肾小球肾炎的模型，观察大黄治疗后纤维连接素的变化及其对系膜区面积的影响。结果：大黄可显著抑制纤维连接素的产生，抑制肾小球系膜区的扩张。结论：大黄通过抑制细胞外基质增生延缓了增生性肾小球肾炎的进行性发展，保护了肾功能。
To study the effect of rhubarb on fibronectin, the main component of glomerular extracellular matrix in rats with proliferative glomerulonephritis. METHODS: Rat nephrotoxic serum nephritis was used as a model for proliferative glomerulonephritis. The changes of fibronectin and its effect on mesangial area after rhubarb treatment were observed. Results: Rhubarb can significantly inhibit the production of fibronectin and inhibit the expansion of mesangial area. Conclusion: Rhubarb retards the progressive development of proliferative glomerulonephritis by inhibiting the proliferation of extracellular matrix and protects renal function.