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[目的]探讨急性有机磷农药中毒(AOPP)患者血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的改变及临床价值。[方法]采用ELISA法检测100例AOPP患者入院时、中毒后12h、48h、72h时的血清NGAL水平和100例健康体检者血清NGAL水平。[结果]AOPP组入院时、中毒后12h、48h、72h时的血清NGAL水平显著高于对照组,两者相比较差异有统计学意义(P﹤0.05);血清NGAL水平随着中毒程度加重而升高,NGAL与不同中毒程度分级呈正相关(r=0.548,P﹤0.01)。[结论]监测AOPP患者血清NGAL水平有助于判断中毒程度,AOPP患者血清NGAL水平的升高对早期急性肾损伤具有重要的诊断价值。
[Objective] To investigate the change and clinical value of serum neutrophil gelatinase-associated lipocalin (NGAL) in patients with acute organophosphorus pesticide poisoning (AOPP). [Methods] Serum NGAL levels of 100 AOPP patients at admission, 12h, 48h, 72h after poisoning and 100 serum NGAL levels of healthy subjects were detected by ELISA. [Results] At the admission of AOPP group, serum NGAL levels at 12h, 48h and 72h after poisoning were significantly higher than those in control group (P <0.05). Serum NGAL levels increased with the increase of poisoning degree There was a positive correlation between NGAL and different levels of poisoning (r = 0.548, P <0.01). [Conclusion] Monitoring serum NGAL levels in patients with AOPP is helpful in judging the degree of poisoning. Elevated serum NGAL level in AOPP patients is of great diagnostic value for early acute kidney injury.