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目的观察脑垂体后叶素联合消心痛治疗肺结核大咯血的临床疗效及不良反应。方法将2006年6月1日～2008年5月31日大咯血的240例病人随机分为治疗组130例及对照组110例。治疗组采用脑垂体后叶素12U加5%葡萄糖250ml每12h一次,消心痛10mg2次/d。对照组病人采用脑垂体后叶素12U加5%葡萄糖250ml每12h一次,观察两组疗效。结果治疗组脑垂体后叶素联合消心痛治疗肺结核大咯血总有效率为97.6%,对照组单独用脑垂体后叶素治疗肺结核大咯血总有效率为67.3%,两组差异有统计学意义(P<0.05),治疗组对血压影响小,无统计学意义(P>0.05),对照组能引起血压升高的副作用(P<0.05);治疗组出现头晕、胸闷、心悸、腹痛、腹泻、恶心呕吐、出汗、面色苍白等不良反应比对照组少,差异有统计学意义(P<0.05)。结论脑垂体后叶素联合消心痛治疗肺结核大咯血的效果比单独用脑垂体后叶素治疗肺结核大咯血效果明显,且能减少垂体后叶素不良反应。
Objective To observe the clinical efficacy and adverse reactions of pituitrin combined with Xiao Hua Tong in the treatment of tuberculosis hemoptysis. Methods A total of 240 patients with massive hemoptysis from June 1, 2006 to May 31, 2008 were randomly divided into treatment group (n = 130) and control group (n = 110). The treatment group using pituitrin 12U plus 5% glucose 250ml once every 12h, heartburn 10mg2 times / d. Control group patients with pituitrin 12U plus 5% glucose 250ml once every 12h, the two groups were observed. Results In the treatment group, the total effective rate of pituitary vasopressin combined with Xiao Hua Tong in the treatment of tuberculosis and hemoptysis was 97.6%. In the control group, the total effective rate of pituitrin alone in treating tuberculosis and hemoptysis was 67.3%. There was significant difference between the two groups (P <0.05). The treatment group had little effect on blood pressure and had no statistical significance (P> 0.05). The control group could cause the side effects of blood pressure increase (P <0.05). The treatment group had dizziness, chest tightness, palpitations, abdominal pain, Nausea and vomiting, sweating, pale and other adverse reactions than the control group, the difference was statistically significant (P <0.05). Conclusions The combination of pituitrin and oxycodinium in the treatment of tuberculosis with hemoptysis is more effective than pituitrin alone in treating tuberculosis with hemoptysis, and it can reduce the adverse reactions of pituitrin.