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[目的]探讨抗精子抗体与不孕不育的相关性。[方法]采用酶联免疫方法(ELISA)检测不孕不育患者血清中抗精子抗体(AsAb),同时选用具有可比性的健康男女做阴性对照。[结果]实验组182例,检出AsAb阳性52例,阳性率28.7%正常对照组AsAb阳性2例,阳性率2.5%,不孕不育组AsAb阳性率明显高于对照组,差异有统计学意义(P﹤0.05)。[结论]AsAb阳性是免疫性致不孕不育的重要原因,ELISA方法敏感度高,实验重复性好,操作简便,对临床原因不明的不孕不育探求病因以及为临床的治疗和预后提供指导。
[Objective] To investigate the correlation between antisperm antibody and infertility. [Methods] Serum anti-sperm antibody (AsAb) was detected by enzyme-linked immunosorbent assay (ELISA), and healthy men and women were selected as negative control. [Results] In the experimental group of 182 cases, 52 cases of positive AsAb were detected, the positive rate was 28.7%. The positive control group had 2 cases of AsAb positive rate, the positive rate was 2.5%. The positive rate of AsAb in infertility group was significantly higher than that in control group Significance (P <0.05). [Conclusion] AsAb positivity is an important reason of immune-induced infertility. ELISA method has high sensitivity, good repeatability and easy operation. It provides a probe into the etiology of infertility with unexplained infertility and clinical treatment and prognosis guide.