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During the early mid-1990s,a number of rural farmers across central China were employed to the unregulated plasmaselling-activity and many of them were infected by HIV-1.However,AIDS progression in the former blood donors(FBDs)is various.The aim of this study is to assess human leukocyte antigen(HLA)class I allele distribution in FBDs and evaluate its association with HIV-1 infection and disease progression.A total of 353 FBDs were enrolled in the cohort including 294 ART na ve HIV-1 seropositive and 59 HIV-1 seronegative age-matched subjects.The viral load and CD4/CD8 T cell counts were assessed in all subjects.Compared with HIV-seropositive group,the frequency of HLA-A*03 in control was significantly higher.After classifying the HLA-B alleles of the subjects according to the presence of Bw4/Bw6 serological epitopes,detrimental effect of HLA Bw6/Bw6 homozygosity was also confirmed in the HIV-seropositive subjects.This study provides novel evidence on HLA class I allele distribution and association of HLA-A*03 frequency with HIV-1 infection and viremia in the HIV-1 infected FBDs,which may throw light on intervention strategy for the HIV-1 infection and our understanding how host immunity and genetic background affect HIV infection and AIDS progression.
During the early mid-1990s, a number of rural farmers across central China were employed to the unregulated plasmaselling-activity and many of them were infected by HIV-1.However, AIDS progression in the former blood donors (FBDs) is various.The aim of this study is to assess human leukocyte antigen (HLA) class I allele distribution in FBDs and evaluate its association with HIV-1 infection and disease progression. A total of 353 FBDs were enrolled in the cohort including 294 ART na ve HIV-1 seropositive and 59 HIV-1 seronegative age-matched subjects. The viral load and CD4 / CD8 T cell counts were assessed in all subjects.Compared with HIV-seropositive group, the frequency of HLA-A * 03 in control was significantly higher. After classifying the HLA-B alleles of the subjects according to the presence of Bw4 / Bw6 serological epitopes, detrimental effect of HLA Bw6 / Bw6 homozygosity was also confirmed in the HIV-seropositive subjects.This study provides novel evidence on HLA class I allele distribution an d association of HLA-A * 03 frequency with HIV-1 infection and viremia in the HIV-1 infected FBDs, which may throw light on intervention strategy for the HIV-1 infection and our understanding how host immunity and genetic background affect HIV infection and AIDS progression.