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目的:了解贵州省黔南州部分成人高尿酸血症(Hyperuricemia,HUA)的患病情况及其影响因素,为针对该地区人群HUA防治策略的制定提供依据。方法:随机抽取黔南州都匀市两所医院的12808例体检人群的生理生化结果进行分析。结果:调查对象中HUA的检出率为24.06%(3081/12808)。其中男性检出率为34.47%(2701/7837),女性为7.64%(380/4971),且男性HUA检出率明显高于女性,差异有统计学意义(X2=1136.1,P=0.000);按年龄段分析发现,女性血尿酸水平和HUA的检出率随年龄的增长而升高,而男性血尿酸水平未见随年龄增长而升高的趋势;多元逐步回归分析发现,舒张压、甘油三酯、肌酐、体质指数、低密度脂蛋白与尿酸水平呈正相关关系,高密度脂蛋白、空腹血糖与血尿酸水平呈负相关关系。结论:黔南州体检人群中HUA检出率较高,且男性显著高于女性,发生有低龄化趋势,同时发现HUA与体内多项代谢指标异常有相关性。
Objective: To understand the prevalence and influencing factors of some adult hyperuricemia (HUA) in Qiannan Prefecture of Guizhou Province, and to provide basis for the formulation of the strategy of HUA prevention and control in this area. Methods: Physiological and biochemical results of 12 808 physical examination population in two hospitals in Duyun City, Qiannan Prefecture were randomly selected for analysis. Results: The detection rate of HUA in the surveyed subjects was 24.06% (3081/12808). Among them, the detection rate of male was 34.47% (2701/7837) and that of female was 7.64% (380/4971), and the detection rate of male HUA was significantly higher than that of female (X2 = 1136.1, P = 0.000). According to the analysis of age groups, the level of serum uric acid and the detection rate of HUA increased with the increase of age, while the level of serum uric acid in men did not increase with age. Multivariate stepwise regression analysis showed that diastolic blood pressure, Triester, creatinine, body mass index, low density lipoprotein and uric acid levels were positively correlated, high density lipoprotein, fasting blood glucose and serum uric acid levels were negatively correlated. CONCLUSION: The prevalence of HUA in Qiannan state is high, and the male is significantly higher than that of female. There is a trend of younger age. At the same time, it is found that there is a correlation between HUA and many metabolic indexes in the body.