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目的探讨胰岛素样生长因-子1(insulin-like growth factor-1,IGF-1)与脑胶质瘤发生的关系。方法67例脑胶质瘤患者按病理分级标准分为高级别组和低级别组,以30例健康人作为对照组。比较正常人及胶质瘤患者手术前后血清IGF-1含量。结果高级别组脑胶质瘤患者血清中IGF-1水平显著高于低级别组IGF-1水平,且均显著高于正常人;脑胶质瘤患者手术后血清IGF-1水平较手术前显著下降。结论脑胶质瘤患者血清IGF-1表达水平可以反映肿瘤恶性程度及治疗预后。
Objective To investigate the relationship between insulin-like growth factor-1 (IGF-1) and glioma. Methods Sixty-seven patients with glioma were divided into high-grade group and low-grade group according to pathological grading standards, and 30 healthy individuals as control group. The serum IGF-1 levels in patients with normal and glioma before and after surgery were compared. Results Serum levels of IGF-1 in patients with high-grade glioma were significantly higher than those in patients with low-grade glioma and were significantly higher than those in normal controls. Serum IGF-1 levels after glioma surgery were significantly higher than those before operation decline. Conclusion The level of serum IGF-1 in glioma patients can reflect the degree of malignancy and prognosis.