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吗啡与内源性类吗啡物质的中枢作用机制尚末完全阐明。近年来有人(Longo1962,Bradley 1968,Navarro 1971)观察对脑电(E E G)皮层诱发电位(Ruben,1979 Heranndez.1981)以及脑不同部位细胞放电的影响。过去我们的工作也曾观察过吗啡对刺激猫牙髓所引起的皮层诱发电位的抑制作用。但用粗电极或一般脑电的记录方法,很难找出有特殊意义的变化。用微电泳的方法观察吗啡与内源性类吗啡物质对脑细胞放电的影响近来报导颇多(见North 1979的综述)。用微电泳,所给药物直接作用于所记录的细胞,实验结果便于分析,但作用较为局限,也不可能同时观察动物的行
The central mechanism of action of morphine and endogenous morphine substances is yet to be fully elucidated. In recent years, some people (Longo1962, Bradley1968, Navarro1971) observed on the EEG (Een G) cortical evoked potentials (Ruben, 1979 Heranndez.1981) and different parts of the brain cells discharge. In the past, our work has also observed the inhibitory effect of morphine on cortical evoked potentials induced by dental pulp in cats. However, with a coarse electrode or general brain recording method, it is difficult to identify changes with special significance. The effect of morphine and endogenous morphine species on brain cell discharge has been reported recently using microelectrophoresis (see North 1979 review). Microelectrophoresis, the given drug directly on the recorded cells, the experimental results easy to analyze, but the role is more limited, it is impossible to observe the animal’s line