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端粒酶(telomerase)是一种合成端粒序列的核糖核蛋白复合物,主要由端粒酶逆转录酶(the telomerase reverse transcriptase,TERT)、端粒酶RNA(the telomerase RNA component,TERC)及与酶活性和组装相关的一些蛋白质组成。端粒酶能使端粒的长度和结构得以稳定,从而保护染色体。已有大量研究显示,其在细胞永生化和肿瘤发生发展过程中
Telomerase is a ribonucleoprotein complex that synthesizes telomere sequences and is mainly composed of the telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) and Some proteins are involved in enzyme activity and assembly. Telomerase can telomere length and structure can be stabilized, thus protecting the chromosome. A large number of studies have shown that in the process of cell immortalization and tumorigenesis