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目的研究磷酸肌酸在治疗新生儿重度窒息心肌损害的临床效果,为重度窒息心肌损害的临床治疗提供参考。方法将68例新生儿窒息伴重度心肌损害的新生儿随机分为治疗组及对照组,对照组采用常规治疗,治疗组在常规治疗的基础上加用磷酸肌酸治疗,疗程为7d。比较两组新生儿治疗前后心肌酶谱的变化,并评价两组新生儿的治疗效果。结果用磷酸肌酸治疗后,治疗组的效果(79.41%)明显优于对照组(50.0%),并且治疗组的磷酸肌酸激酶(121.2±64.3)、磷酸肌酸激酶同工酶(22.4±11.3)、乳酸脱氢酶(102.2±45.3)、羟丁酸脱氢酶(146.2±102.4)、谷草转氨酶(30.2±10.2)等均明显小于对照组,差异有统计学意义(P<0.05)。结论在重度的新生儿窒息伴心肌损害的治疗中,常规治疗的基础上加用磷酸肌酸有助于提高治疗效果,有利于降低心肌酶谱水平。
Objective To study the clinical effect of creatine phosphate in the treatment of neonatal severe asphyxia myocardial injury and provide a reference for the clinical treatment of severe asphyxia myocardial damage. Methods Neonates of 68 neonates with asphyxia and severe myocardial damage were randomly divided into treatment group and control group. The control group was treated with conventional therapy. The treatment group was treated with phosphocreatine for 7 days on the basis of routine treatment. The changes of myocardial enzymes before and after treatment were compared between the two groups, and the therapeutic effect of the two groups of newborns was evaluated. Results After treatment with creatine phosphate, the effect of the treatment group (79.41%) was significantly better than that of the control group (50.0%), and the creatine phosphokinase (121.2 ± 64.3), creatine phosphokinase isoenzyme (22.4 ± 11.3), lactate dehydrogenase (102.2 ± 45.3), hydroxybutyrate dehydrogenase (146.2 ± 102.4) and aspartate aminotransferase (30.2 ± 10.2) were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusions In the treatment of severe neonatal asphyxia with myocardial damage, the addition of routine administration of creatine phosphate may help to improve the therapeutic effect and reduce the level of myocardial enzymes.