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目的分析早产儿生后早期(2h内)使用固尔苏预防早产儿呼吸窘迫综合征(neonatal respiratory disease syndrome,NRDS)的临床疗效。方法将65例胎龄27～32周,体重900～1 500g的早产儿随机分为两组,治疗组30人,生后2h内气管内滴入固尔苏,剂量100～200mg/kg;对照组35人不用固尔苏,仅给予通畅呼吸道、氧疗,两组患儿均给予相同的综合治疗,比较两组发生NRDS的比例,需要呼吸机治疗的比例、机械通气的时间及胸片改变的严重程度。同时在生后12h内监测血气分析。结果 1)治疗组发生NRDS的比例,需要呼吸机治疗的例数及上机时间较对照组少,两者比较差异有统计学意义(P<0.05);2)两组发生NRDS的患儿胸片改变治疗组比对照组程度轻;3)48h内各时段PaO2、PaCO2、PH治疗组与对照组比较均有明显改善。结论对具有发生NRDS高风险的早产儿生后早期预防性应用固尔苏可以降低NRDS发病率、减轻NRDS的严重程度,减少并发征。
Objective To analyze the clinical efficacy of Gulbutolol in the prevention of neonatal respiratory disease syndrome (NRDS) in premature infants (2h). Methods 65 cases of gestational age 27 to 32 weeks, weight 900 ~ 1500g of premature children were randomly divided into two groups, the treatment group of 30 people, within 2h after birth, tracheal instillation of solid Seoul Su, dose 100 ~ 200mg / kg; control The group of 35 people did not use Cure Su, only given unobstructed airway and oxygen therapy. Both groups were given the same comprehensive treatment. The proportions of NRDS, need of ventilator treatment, time of mechanical ventilation and chest radiographs were compared The severity of Blood gas analysis was monitored within 12 hours after birth. Results 1) The proportion of NRDS in the treatment group required fewer ventilator-treated patients and less time on the machine than those in the control group (P <0.05); 2) Slice change treatment group lighter than the control group; 3) within 48h PaO2, PaCO2, PH treatment group compared with the control group were significantly improved. CONCLUSIONS: Premature neonatal preterm infants with high risk of developing NRDS may have a lower incidence of NRDS, reduce the severity of NRDS, and reduce the incidence of complications.