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目的 探讨p73和c fos蛋白在血管瘤组织中的发生、发展及临床意义。方法 采用免疫组织化学检测增生期血管瘤、退化期血管瘤及正常皮肤组织中p73和c fos蛋白的表达。结果 在血管瘤增生期中p73和c fos蛋白有较高表达 ;退化期血管瘤和正常皮肤组 ,p73和c fos表达极弱。增生期血管瘤与退化期血管瘤、正常皮肤组分别相比 ,p73和c fos蛋白阳性表达均有统计学意义 (P <0 0 1) ,退化期血管瘤与正常皮肤组 ,p73和c fos蛋白阳性表达的差异均无统计学意义 (P >0 0 5 )。结论 p73和c fos蛋白在血管瘤的发生、发展及其演变过程中起着重要的作用。
Objective To investigate the occurrence, development and clinical significance of p73 and c fos proteins in hemangiomas. Methods The expressions of p73 and c fos protein in proliferating hemangioma, degenerative hemangioma and normal skin tissue were detected by immunohistochemistry. Results The expression of p73 and c fos proteins were higher in the proliferative phase of hemangiomas. The expressions of p73 and c fos were extremely weak in the hemangiomas and normal skin tissues. The expression of p73 and c fos in proliferating hemangioma was significantly higher than that in degenerative hemangioma and normal skin (P <0.01), and the degenerative hemangioma was significantly different from that in normal skin, p73 and c fos There was no significant difference in protein positive expression (P> 0.05). Conclusion The p73 and c fos proteins play an important role in the occurrence, development and progression of hemangiomas.