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维生素K_3在国内外主要作为凝血药使用,关于解痉作用及治疗胆道蛔虫所致胆绞痛未见报导。在党的“十大”精神鼓舞下,我所药物研究室同志根据维生素K_3的化学结构与我区治疗胆绞痛效果较好的草药搬倒甄根的有效成份矶松素(Plumbagin)的化学结构相似,和具有解痉作用的胡椒酮(Piperitone)的β—甲基—α,β—烯酮药效基团,根据化学结构与活性关系分析,甲萘醌可能具有同样的作用。对维生素K_3进行了松弛离体兔肠肌实验,结果证明维生素K_3确有强的解痉作用。在此基础上,于1973年12月在地区医院门诊医生的协作下进行临床观察,治疗胆道蛔虫所致胆绞痛20例,有效18例,其中15～60分钟疼痛完全消失13例,
Vitamin K_3 is mainly used as coagulation drug in domestic and foreign countries. There is no report about the antispasmodic effect and the treatment of biliary angina caused by biliary ascariasis. Inspired by the “top ten” spirit of the party, our lab, based on the chemical structure of vitamin K_3 and our district, took effective remedies for the treatment of biliary colic with the active ingredients of Plumbagin Structurally similar, and with antispasmodic piperitone β-methyl - α, β - enone pharmacophore, according to the chemical structure and activity analysis, menadione may have the same effect. Relaxation of vitamin K_3 in vitro rabbit intestinal muscle test results show that vitamin K_3 indeed strong antispasmodic effect. On this basis, in December 1973 in the district hospital outpatient clinic in collaboration with clinical observation, treatment of biliary ascaris induced biliary colic 20 cases, 18 cases effective, of which 15 to 60 minutes of pain disappeared completely in 13 cases,