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很多血管活性物质通过肺循环时被部分灭活。离体灌注肺的研究证明,肺对单胺的摄取与肺动脉血管内皮细胞有关,而肺血管疾病可影响肺的这种功能。作者用放射酶法测定正常肺动脉压者和肺动脉高压病人的肺对去甲肾上腺素(NE)、肾上腺素(E)和多巴胺(DA)的摄取。24例病人以右心导管测定平均肺动脉压和肺血管阻力,并插左心导管至降主动脉,同时抽取主动脉和
Many vasoactive substances are partially inactivated by the pulmonary circulation. In vitro perfusion lung studies have shown that lung uptake of monoamine and pulmonary artery endothelial cells, and pulmonary vascular disease can affect this function of the lungs. The authors determined the uptake of norepinephrine (NE), epinephrine (E) and dopamine (DA) in the lungs of patients with normal pulmonary hypertension and pulmonary hypertension by radioimmunoassay. Twenty-four patients underwent right heart catheterization to measure mean pulmonary arterial pressure and pulmonary vascular resistance. The left cardiac catheter was inserted into the descending aorta and the aorta was drawn