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选用32只豚鼠。实验组16只于左侧中耳内每天注射庆大霉素1次,共7或14天,停药后2天杀死。借助相差显微镜、扫描电镜和耳蜗电图观察。结果发现实验组与对照组比较有非常显著性差别(P<0.01)。注射庆大霉素14天的动物柯替氏器显示广泛地变性。扫描电镜观察发现注射庆大霉素7或14天的动物从蜗底到蜗顶仅残留少量的外毛细胞,内毛细胞也大量消失。前庭感受器损害较严重。耳蜗电图显示AP低反应或完全消失。提示庆大霉素应慎用或避免中耳局部应用。
Choose 32 guinea pigs. In the experimental group, 16 rabbits were injected with gentamicin once daily for 7 days or 14 days in the left middle ear and killed 2 days after the withdrawal. With phase contrast microscopy, scanning electron microscopy and cochlear electrogram observation. The results showed that there was a significant difference between the experimental group and the control group (P <0.01). Guinea pigs injected gentamicin for 14 days showed extensive degeneration. Scanning electron microscopy showed that animals injected with gentamycin for 7 or 14 days left only a small amount of outer hair cells from the bottom of the cochlea to the cochlea, and the inner hair cells also disappeared in large numbers. Vestibular receptors damage more serious. The cochlearogram showed low response or complete disappearance of AP. Tips gentamicin should be used with caution or avoid local application of the middle ear.