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目的探讨治疗肺癌脑转移的有效途径和方法，改善病人生存质量，延长病人生存期。方法应用以威猛为主的化疗方案配合放疗治疗２２例，放疗应用６０Ｃｏ行全脑照射后再缩野追加照射，使肿瘤局部照射剂量达５０Ｇｙ左右；化疗以威猛为主组合方案，配以顺铂（或卡铂）、５－氟尿嘧啶２～３药联合，每４周为１疗程，共进行２～４疗程。结果２２例中完全缓解２例（９％）、部分缓解１３例（５９％）、稳定６例（２７％）、无效１例（５％），总有效率为６８％．中位生存期８．３个月。不良反应轻微。结论该治疗方法对肺癌脑转移病人比较合理而有效，其不足是威猛、卡铂价格昂贵，尚不易普及应用。
Objective To explore effective ways and methods for treating brain metastases of lung cancer, improve the quality of life of patients, and prolong the survival of patients. METHODS: Twenty-two patients were treated with a predominantly chemotherapy-based chemotherapy regimen combined with radiotherapy. Radiotherapy was performed with 60Co whole-brain irradiation and then additional field irradiation. The local irradiation dose of the tumor was approximately 50 Gy. Chemotherapy was based on a combination of fiercerism and chemotherapy. Cisplatin (or carboplatin), 5-fluorouracil 2 to 3 drugs combined, every 4 weeks for a course of treatment, a total of 2 to 4 courses of treatment. Results In 22 cases, 2 cases (9%) completely resolved, 13 cases (59%) partially relieved, 6 cases (27%) stable, and 1 case (5%) stable. The total effective rate was 68%. The median survival period is 8.3 months. The adverse reaction was slight. Conclusion This treatment method is more reasonable and effective for patients with brain metastases from lung cancer. Its deficiency is that it is fierce and carboplatin is expensive. It is not easy to popularize it.