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氯苄哌醚联苯酰苯酸盐主要用于止咳,L-氯苄哌醚联苯酰苯酸盐具有更高活性.采用手性色谱柱,建立了氯苄哌醚联苯酰苯酸盐光学异构体的拆分方法,并将其用于氯苄哌醚联苯酰苯酸盐的检测.结果表明,采用Chiralcel OD-H柱,在流动相V(正己烷)∶V(异丙醇)∶V(二乙胺)=98∶2∶0.1的条件下,2个异构体能同时达到基线分离,检测波长为254nm,氯苄哌醚联苯酰苯酸盐检测极限为10ng.这表明所建立的分离分析方法可方便可靠地用于该化合物的光学纯度检测.
Chlorobenzopentiphenyl dibenzamide is mainly used for cough prevention, and L -chlorobenzopendiphenyl dibenzoate is more active.Using chiral column, The optical isomers were resolved and used for the determination of clofluoperoxyphenylacetic acid.Results showed that the chromatographic conditions were as follows: Chiralcel OD-H column was used in mobile phase V (n-hexane): V Alcohol): V (diethylamine) = 98: 2: 0.1, the two isomers can achieve baseline separation at the same time, the detection wavelength is 254nm, and the detection limit of clofenzobiphenyl benzoate is 10ng. It shows that the established analytical method can be used for the optical purity of this compound easily and reliably.