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收集贵州地区100例T细胞淋巴瘤进行EB病毒检测。用免疫组织化学方法确定肿瘤细胞的T细胞表型;用聚合酶链反应检测EB病毒特征性的DNA序列(EBV-DNA);用原位杂交法检测EB病毒编码的RNA(EBER1/2)。研究结果表明,贵州地区T细胞淋巴瘤与EB病毒关系极为密切。EB病毒在鼻咽部T细胞淋巴瘤中起着一定的作用,淋巴母细胞性T细胞淋巴瘤与EB病毒有一定的关系。
100 cases of T-cell lymphoma in Guizhou were collected for Epstein-Barr virus detection. The tumor cell T-cell phenotype was determined by immunohistochemistry; the Epstein-Barr virus-characterized DNA sequence (EBV-DNA) was detected by polymerase chain reaction; and Epstein-Barr virus-encoded RNA (EBER1/2) was detected by in situ hybridization. The results of the study showed that there is a close relationship between T-cell lymphoma and Epstein-Barr virus in Guizhou. Epstein-Barr virus plays a certain role in nasopharyngeal T-cell lymphoma, and lymphoblastic T-cell lymphoma has a certain relationship with Epstein-Barr virus.