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目的:为了解P53蛋白异常表达与非小细胞肺癌(NSCLC)预后的关系.方法:采用S-P免疫组织化学法,检测90例手术切除的NSCLC组织石蜡包埋标本.结果:53.3%(48/90)的标本显示P53蛋白向染色阳性.肺鳞癌和腺癌的阴性率分别为64.3%(36/56)和35%(12/34).统计学分析显示P53蛋白染色结果与病人年龄、性别及肿瘤分期无显著关系,但与肿瘤组织类型显著相关.P53蛋白染色阳性和阴性组病人中位生存月数分别是24个月和55个月.Kaplan-Meir图显示二组病人术后生存概率有明显差异.逐步回归多因素分析显示P53蛋白染色阳性与病人术后生存时间呈显著负相关.结论:P53蛋白异常表达是非小细胞肺癌预后不良的独立判断指标.
OBJECTIVE: To investigate the relationship between the abnormal expression of P53 protein and the prognosis of non-small cell lung cancer (NSCLC). Methods: SP immunohistochemistry was used to detect paraffin-embedded specimens of 90 surgically resected NSCLC. Results: 53.3% (48/90) The specimens showed positive staining for P53 protein. The negative rates of lung squamous cell carcinoma and adenocarcinoma were 64.3% (36/56) and 35% (12/34), respectively. Statistical analysis showed that the P53 protein staining results were related to the patient’s age and gender. There was no significant relationship between tumor stage and tumor stage, but it was significantly associated with tumor tissue type. The median survival months for patients with positive and negative staining for P53 protein were 24 months and 55 months, respectively. Kaplan-Meir plot shows the survival probabilities of the two groups of patients. There were significant differences. Stepwise regression multivariate analysis showed that the positive staining of P53 protein was significantly negatively correlated with postoperative survival time. Conclusion: Abnormal expression of P53 protein is an independent indicator of poor prognosis of non-small cell lung cancer.