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目的观察重度颈动脉狭窄患者采用氯吡格雷与拜阿司匹林联合用药治疗的临床效果。方法选取医院进行治疗的患有重度颈动脉狭窄但拒绝行血管内治疗的患者74例作为研究对象,随机分为对照组和试验组,每组37例。对照组采用阿托伐他汀与拜阿司匹林联合用药治疗,试验组采用氯吡格雷与拜阿司匹林联合用药进行治疗。观察2组患者在用药治疗1年后的相关病症发生情况及对治疗效果的满意程度。结果试验组短暂性脑缺血及再发脑梗死发生率分别为8.11%、2.70%,低于对照组的27.03%、16.22%(P均<0.05);但2组脑出血发生率比较差异无统计学意义(P>0.05)。试验组患者治疗总满意度为91.89%,高于对照组的72.97%(P<0.05)。结论采用氯吡格雷与拜阿司匹林联合用药治疗重度颈动脉狭窄临床效果显著,可广泛推广应用。
Objective To observe the clinical effect of combined treatment of clopidogrel and aspirin in patients with severe carotid artery stenosis. Methods Totally 74 patients with severe carotid artery stenosis who refused to undergo endovascular treatment were selected as the study subjects and randomly divided into control group and experimental group with 37 cases in each group. The control group was treated with atorvastatin combined with aspirin, and the experimental group was treated with clopidogrel combined with aspirin. Two groups of patients in the treatment of 1 year after the occurrence of the relevant conditions and the satisfaction of the treatment effect. Results The incidences of transient ischemic attack and recurrent cerebral infarction were 8.11% and 2.70% respectively in the experimental group, which were lower than those in the control group (27.03% and 16.22%, P <0.05). However, the incidence of cerebral hemorrhage in the two groups was no significant difference Statistical significance (P> 0.05). The total satisfaction of the trial group was 91.89%, which was higher than that of the control group (72.97%, P <0.05). Conclusion Clopidogrel and aspirin combined treatment of severe carotid artery stenosis has a significant clinical effect, which can be widely applied.