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目的探讨早期应用氨茶碱对窒息新生儿肾功能的影响。方法 112例窒息新生儿,轻度窒息组76例,重度窒息组36例。每组患儿又随机分成试验组和对照组。在生后1h内试验组静脉滴注小剂量氨茶碱(5mg/kg),对照组静脉滴注等量注射用水,分别收集生后1、3、5d时尿液查尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)活性及β2微球蛋白,并每4h监测记录心率、呼吸、血压。结果在生后3、5d氨茶碱试验组尿NAG活性及β2微球蛋白明显低于对照组(P<0.05),有统计学意义。心率、呼吸、血压无明显差异(P>0.05)。结论早期应用氨茶碱能降低窒息新生儿尿NAG活性及β2微球蛋白,改善肾脏功能,对窒息新生儿肾脏有保护作用。
Objective To investigate the effects of early application of aminophylline on renal function in neonates with asphyxia. Methods 112 asphyxiated newborns, 76 asymptomatic asphyxia group and 36 asphyxia group. Each group of children were randomly divided into experimental group and control group. The experimental group intravenous infusion of small doses of aminophylline (5mg / kg) in the experimental group within 1h after birth, the control group intravenous infusion of equal amount of water, were collected at 1,3,5 days after birth urinalysis urine N-acetyl-β -D-glucosaminidase (NAG) activity and β2 microglobulin, and monitoring every 4h heart rate, respiration, blood pressure. Results The urinary NAG activity and β2-microglobulin in aminophylline group were significantly lower than those in control group (P <0.05) on the 3rd and 5th day after birth. Heart rate, respiration, blood pressure no significant difference (P> 0.05). Conclusion Early application of aminophylline can reduce urinary NAG activity and β2 microglobulin in neonatal asphyxia, improve renal function, and protect neonatal asphyxia neonatorum.