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目的观察对于血糖控制不理想的II型糖尿病患者应用甘精胰岛素和赖脯胰岛素的临床效果。方法选取2008年5月至2010年5月治疗的42例血糖控制不理想的II型糖尿病患者,其中研究组21例采用甘精胰岛素联合赖脯胰岛素治疗,对照组21例采用诺和灵R联合诺和灵N治疗。比较两组间胰岛素用量、餐后2h血糖、空腹血糖,血糖达标时间和夜间低血糖发生率等治疗效果。结果采用甘精胰岛素联合赖脯胰岛素的研究组的胰岛素用量小,餐后2h血糖理想,空腹血糖理想,血糖达标时间短,夜间低血糖发生率低且均优于采用诺和灵R联合诺和灵N治疗的对照组(P<0.05)。结论甘精胰岛素联合赖脯胰岛素降糖效果好,夜间低血糖发生率低,可有效的治疗血糖控制不理想的II型糖尿病患者。
Objective To observe the clinical effects of insulin glargine and insulin lispro on type 2 diabetes patients with poor glycemic control. Methods Forty-two patients with type 2 diabetes who did not control glycemic control were selected from May 2008 to May 2010. 21 cases in the study group were treated with insulin glargine and insulin lispro and 21 cases in the control group were treated with Novolin R Nuo Ling N treatment. Compare the amount of insulin between the two groups, 2h postprandial blood glucose, fasting blood glucose, blood glucose compliance time and the incidence of nocturnal hypoglycemia and other therapeutic effects. Results The study group with insulin glargine and insulin lispro had less insulin, ideal blood glucose at 2h postprandial, ideal fasting blood glucose, shorter time to blood glucose, lower nocturnal hypoglycemia than both Norvanol Ling N treatment control group (P <0.05). Conclusion Glargine and insulin lispro have a good hypoglycemic effect and a low incidence of hypoglycemia at night, which can effectively treat type 2 diabetes patients with poor blood sugar control.