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业已表明氯乙烯对大鼠和人有致癌性。据报道部分氯乙烯代谢成为极性产物从尿中排出。其转归与剂量有关,并可能有二种以上的代谢途径,根据资料推测氯乙烯的致癌活性是可能通过形成烷化代谢产物,如氯乙醛、氧化氯乙烯所致。作者采用~(14)G-氯乙烯(放射化学纯度95～96%),对大鼠进行经口和吸入染毒的药理动力学和代谢的研究。[方法]成年雄性大鼠,4～5只为一组。吸入染毒共二组,分别吸入氯乙烯10和1,000ppm 6小时,比括性分别为4,848(10 ppm)和
It has been shown that vinyl chloride is carcinogenic to rats and humans. It is reported that part of the vinyl chloride metabolism as a polar product excreted from the urine. Its outcome is dose-dependent and may have more than two metabolic pathways. According to the data, it is speculated that the carcinogenic activity of vinyl chloride may be caused by the formation of alkylating metabolites such as chloroacetaldehyde and vinyl chloride. The authors used ~ (14) G-vinyl chloride (radiochemical purity of 95 ~ 96%), pharmacokinetics and metabolism of rats by oral and inhalation exposure. [Methods] Adult male rats, 4 ~ 5 only one group. Inhalation exposure to a total of two groups were inhaled vinyl chloride 10 and 1,000ppm for 6 hours, respectively, the ratio of 4,848 (10 ppm) and