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目的探讨阿奇霉素治疗小儿支原体感染的临床疗效。方法选取樟树市人民医院2016年2月—2017年1月收治的小儿支原体感染患儿84例,按照随机数字表法分为阿奇霉素治疗组与红霉素治疗组,各42例。红霉素治疗组予以红霉素治疗,阿奇霉素治疗组予以阿奇霉素治疗,两组患儿均治疗1~2个疗程。比较两组患儿临床疗效,治疗前后体温、C反应蛋白(CPR)水平、白细胞计数,体温恢复正常时间、支原体转阴时间、住院时间,观察两组患儿不良反应发生情况。结果阿奇霉素治疗组患儿治疗总有效率高于红霉素治疗组(P<0.05)。治疗前两组患儿体温、CPR水平、外周血白细胞计数比较,差异无统计学意义(P>0.05);治疗后阿奇霉素治疗组CPR水平、白细胞计数低于红霉素治疗组,治疗后两组患儿体温、CPR水平、白细胞计数低于治疗前(P<0.05);治疗后两组患儿体温比较,差异无统计学意义(P>0.05)。阿奇霉素治疗组体温恢复正常时间、支原体转阴时间、住院时间短于红霉素治疗组(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿奇霉素治疗小儿支原体感染的临床疗效确切,可有效控制感染,有效改善临床症状,缩短治疗时间,且安全性较高。
Objective To investigate the clinical efficacy of azithromycin in treating children with mycoplasma infection. Methods Eighty-four children with mycoplasma infection in children admitted from February 2016 to January 2017 in Zhangshu People’s Hospital were divided into azithromycin treatment group and erythromycin treatment group according to the random number table. Erythromycin treatment group to erythromycin treatment, azithromycin treatment group to azithromycin treatment, two groups of children were treated for 1 to 2 courses. The clinical efficacy, body temperature, C-reactive protein (CPR) level, white blood cell count, body temperature recovery time, mycoplasma negative conversion time and hospitalization time were compared between the two groups. The incidence of adverse reactions in both groups were observed. Results The total effective rate of azithromycin treatment group was higher than that of erythromycin treatment group (P <0.05). There was no significant difference in body temperature, CPR level and peripheral blood leukocyte count between the two groups before treatment (P> 0.05). After treatment, the CPR level and the leukocyte count in the azithromycin treatment group were lower than those in the erythromycin treatment group. After treatment, The body temperature, CPR level and white blood cell count in children were lower than those before treatment (P <0.05). There was no significant difference in body temperature between the two groups after treatment (P> 0.05). Azithromycin treatment group normal temperature recovery, mycoplasma negative time, hospital stay shorter than the erythromycin group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Azithromycin treatment of children with mycoplasma infection clinical efficacy of the exact, effective control of infection, effective in improving clinical symptoms, shorten the treatment time, and high safety.