小儿单纯性肥胖症遗传倾向的探讨

• 作 者: 马咸成 刘戈力 叶大勋 王秀英 杨箐岩 乔学萍 王秀兰
• 机 构: 天津医科大学总医院儿科,天津医科大学总医院儿科,天津医科大学总医院儿科,天津医科大学总医院儿科,天津医科大学总医院儿科,天津医科大学总医院儿科,天津医科大学总医院儿科
• 出 处: 中国优生优育
• 发表日期: 1994年04期
• 关键词: 单纯性肥胖症 肥胖发生率 一级亲属 先证者 遗传倾向 阳性家族史 易患性 测量身高 系谱分析 二级亲属

木文对单纯性肥胖症4～14岁患儿104例进行体重指数BMI的测算,均值为26.62±2.35;并随机选择体态正常的相应儿童126名作为对照BMI为16.90±1.34。对两组一级亲属遗传学调查,患儿一级亲属肥胖发生率为37.50％,对照一级亲属为13.49％。BMI均呈正态分布。经先证者系谱分析不符合单基因遗传方式。而符合多基因遗传,遗传度为86％。患儿有阳性家族史者占60.57％,尤以双亲皆肥胖和母亲肥胖家系对于代影响显著,提示对高危家庭应予足够重视,加强监测与防治。

In the study of simple obesity in children aged 4 to 14 years, 104 children were measured body mass index (BMI), with a mean of 26.62 ± 2.35. 126 children with normal body weight were selected randomly as the control BMI of 16.90 ± 1.34. Genetic survey of two first-degree relatives, the incidence of obesity in first-degree relatives of children was 37.50% and that of first-degree relatives was 13.49%. BMI were normal distribution. Genealogical analysis by probands did not fit with the single-gene inheritance pattern. In line with polygenic inheritance, geneticity was 86%. Children with positive family history accounted for 60.57%, especially parents are obese and maternal obesity family significant impact on behalf of high-risk families should pay due attention to strengthening monitoring and prevention.