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流行性乙型脑炎患儿合并惊厥３１例（男性１９，女性１２，年龄３．６±ｓ２．３ａ），用氯硝西泮０．０５－０．１ｍｇ／ｋｇ，ｉｖ缓注１次，再同剂量ｉｍ，ｑｄ×３ｄ。另外２９例患儿（男性１７，女性１２，年龄３．３±１．９ａ），用地西泮０．３ｍｇ／ｋｇ，ｉｖ缓注，苯巴比妥５－９ｍｇ／ｋｇ，ｉｍ，均ｑｄ×３ｄ。结果前组显效率８７％，后组３８％，止惊时间前组２．２±０．５ｄ，后组２．７±０．６ｄ，前组优于后组（Ｐ＜０．０１）。＊Ｐ＜０．０１。不良反应缓慢ｉｖ或ｉｍ氯硝西泮，１８例有嗜睡、镇静，１例共济失调伴眩晕，但未见心脏、呼吸抑制情况。讨论氯硝西泮是一种高脂溶性易透过血脑屏障的抗惊厥药，静注后数分钟可达血药浓度峰值并迅速进入脑组织，起效迅速，对惊厥频发者许多病例都是边注射边停止惊厥。本品Ｔ约为２２－３８ｈ，作用持续约６－８ｈ，因此本品具有比地西泮作用迅速，同时又兼有苯巴比妥的持续作用时间长的优点。鉴此，我们应用氯硝西泮治疗小儿流行性乙型脑炎的惊厥频发者。效果令人满意。由于氯硝西泮良好的止惊作用，以及其他药物的积极治疗，我们收治的３１例流行性乙型脑炎全部治愈而无１例死亡。目前尚未发现类似地西泮ｉｖ时发生的呼吸抑制现象。因?
There were 31 cases of convulsion in children with Japanese encephalitis (male 19, female 12, age 3.6 ± s2.3a), once with clonazepam 0.05-0.1 mg / kg, iv, Re-dose im, qd × 3d. Another 29 children (17 males, 12 females, 3.3 ± 1.9 years) were treated with diazepam 0.3 mg / kg, iv bolus, phenobarbital 5-9 mg / kg, im, 3d. Results The effective rate was 87% in the former group, 38% in the latter group, 2.2 ± 0.5d in the former group and 2.7 ± 0.6d in the latter group, and the former group was superior to the latter group (P <0.01). * P <0.01. Adverse reactions slow or iv clonazepam, 18 cases of lethargy, sedation, 1 case of ataxia with dizziness, but no heart, respiratory depression. Discussion Clonazepam is a high fat-soluble easily through the blood-brain barrier anticonvulsant, intravenous infusion of up to several minutes after the peak plasma concentration and rapid access to brain tissue, rapid onset of convulsions in many cases of frequent All while stopping the injection of seizures. This product T is about 22-38h, the role of sustained about 6-8h, so this product has a rapid effect than diazepam, while both phenobarbital long-term advantages. In view of this, we use clonazepam in the treatment of children with epidemic encephalitis convulsions frequent. Satisfactory results. Due to the good anticonvulsant effect of clonazepam and the active treatment of other drugs, all of the 31 Japanese encephalitis cases we treated were cured without any death. No respiratory depression similar to that of diazepam has been observed so far. because?