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目的:评价宫颈LEEP锥切术后用重组人干扰素-α2b凝胶(以下简称“干扰素凝胶”)对高危型人乳头状瘤病毒(HPV)感染的宫颈上皮内瘤变(CIN)患者的疗效。方法:选取2014年1月—2015年1月间收治的高危型HPV感染的CIN患者64例,将其分为观察组和对照组,每组32例;对照组患者给予行宫颈LEEP锥切术治疗,观察组患者在对照组基础上术后给予干扰素凝胶治疗,评价两组患者治疗后的治愈率和HPV阳性率。结果:观察组治疗后的治愈率为96.88%稍高于对照组为90.63%,经组间比较其差异无统计学意义(P>0.05);两组患者术前的HPV阳性率相同,术后6月和12月时观察组患者的HPV阳性率分别为6.25%和3.13%低于对照组分别为25.00%和18.75%(P<0.05)。结论:对高危型HPV感染的CIN患者行宫颈LEEP锥切术后用干扰素凝胶治疗能够抑制HPV感染,降低CIN的复发率。
OBJECTIVE: To evaluate the effect of cervical intraepithelial neoplasia (CIN) associated with high-risk human papillomavirus (HPV) infection after cervical LEEP conization with recombinant human interferon-α2b gel (hereinafter referred to as “interferon gel” ) Patient’s efficacy. Methods: Sixty-four CIN patients with high-risk HPV infection were selected from January 2014 to January 2015, and divided into observation group and control group, with 32 cases in each group. Patients in the control group underwent cervical LEEP conization The patients in the treatment group and the observation group were treated with interferon gel on the basis of the control group, and the cure rate and the HPV positive rate after treatment were evaluated. Results: The cure rate of observation group after treatment was 96.88%, slightly higher than that of control group (90.63%). There was no significant difference between the two groups (P> 0.05) The positive rate of HPV in observation group was 6.25% and 3.13% respectively in June and December, which was 25.00% and 18.75% respectively (P <0.05). CONCLUSIONS: In patients with high-risk HPV infection, CIN patients undergoing LEEP conization can inhibit HPV infection and reduce the recurrence rate of CIN.