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本文用Ａｍｅｓ试验、小鼠骨髓微核试验及人外周血淋巴细胞染色体畸变试验研究了卡铂的致灾变作用，同时用受孕大鼠研究了卡铂的致畸胎作用。结果表明，该药只有显著的致空变及胚胎毒作用。在Ａｍｅｓ试验中，卡铂浓皮１０，１００，５００，１０００和５０００μｇ／对ＴＡ１０２菌株均有显著的回复突变作用，在微核试验中，卡铂２０，４０，６０ｍｇ／Ｋｇ剂量组均诱发微核率显著增高，大剂量组高达８６％。在染色体畸变试验中，卡铂引起染色体畸变率５．０μｇ／ｍｌ组为１２．０％（－Ｓ９）；１０．０％（＋Ｓ９）；５０．０ｇ／ｍｌ组为２１．０％（－Ｓ９），１８．０％（＋Ｓ９）。与对照组比较有显著差异。大鼠致畸胎试验表明，卡铂２０ｍｇ／ｋｇ间隔２日给药２次，具有明显的胚胎毒作用，死胎率达４１．７％，多肋率为２２，６％，但未见外观及内脏器官畸形。
In this paper, Ames test, mouse bone marrow micronucleus test and human peripheral blood lymphocyte chromosome aberration test was used to study the catastrophe catastrophe effect, while using pregnant rats to study the role of carboplatin teratogenic. The results show that the drug only significant empty change and embryo toxicity. In the Ames test, carboplatin concentrated 10,100,500,1000 and 5000μg / TA102 strains have a significant role in the recovery of mutations in the micronucleus test, carboplatin 20,40,60 mg / Kg dose groups were induced micro Nucleus rate was significantly higher, high-dose group up to 86%. In the chromosomal aberration test, carboplatin caused a rate of chromosome aberration of 5.0% in the 5.0 μg / ml group (12.0%, --S9), 10.0% (+ S9), and 21.0% in the 50.0 g / ml group ), 18.0% (+ S9). Compared with the control group there are significant differences. Teratogenicity test in rats showed that carboplatin 20 mg / kg was administered twice on the 2nd day with obvious embryotoxicity, the stillbirth rate was 41.7% and the multi-rib ratio was 22.6% Internal organ deformity.