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中医临床治疗学主要是基于整体“证候”诊断的中药复方治疗学。其“证候”病理基础是多样的,复方化学成分是多样的,药物作用途径、环节和靶点也是多样的。实际上这是一个高度的复杂体,故有人称中医为“复杂科学”。很显然,采用单因素分析方法和检测技术,如寻找某些单一病理分子与中医“证候”的关联,分离中药单一化学成分研究中药治病的作用机理等,并不适合中医学整体治疗和复方用药的特点。系统生物学理论与组学技术(如蛋白质组、代谢组、基因组等)的发展与应用,为克服上述矛盾提供了条件,因为组学技术能够动态、高效地测定机体在整体条件和多因素作用下多种蛋白质大分子及多种小分子的谱学特征,以及描述多分子间的相互作用规律。因此,组学技术将是研究中医“复杂科学”的强大工具,为揭示中医“证候”的发生机理、体质学说的科学内涵、中药复方治疗复杂性疾病的作用原理等重大科学问题提供了可能。当然,采用组学技术研究中医药,尤其要注意严谨的科学设计,以及研究对象和干预因素的标准化和一致性,同时采用生物信息学和计算机科学等分析海量数据的相互关联。这样,便能建立一个适合中医学研究特点的、优质高效的组学技术平台,大力推动传统中医药理论和经验与现代科学的合理结合,以及中医药现代化。
TCM clinical therapy is mainly based on the overall “syndrome ” diagnosis of Chinese medicine compound therapy. The “syndrome ” pathological basis is diverse, complex chemical composition is diverse, the drug route of action, links and targets are varied. In fact, this is a highly complex body, so some people call it “complicated science”. Obviously, using single factor analysis and detection techniques, such as looking for the association of some single pathological molecules with TCM syndromes and separating the single chemical constituents of traditional Chinese medicine from the mechanism of traditional Chinese medicine treatment are not suitable for the whole Chinese medicine Treatment and compound medication characteristics. The development and application of system biology theory and omics technology (such as proteome, metabolome, genome, etc.) provide the conditions for overcoming the above contradictions. Because omics technology can dynamically and efficiently determine the body’s overall condition and multi-factor effect Under a variety of protein macromolecules and a variety of small molecule spectroscopy characteristics, as well as the description of the interaction between multi-molecular rules. Therefore, omics technology will be a powerful tool for studying TCM “complex science ”. In order to reveal the mechanism of TCM “syndrome ”, the scientific connotation of physique theory and the action principle of TCM compound in treating complex diseases, The problem is possible. Of course, the use of omics technology to study Chinese medicine, with particular attention to rigorous scientific design, as well as the standardization and consistency of research objects and interventions, as well as the use of bioinformatics and computer science to analyze the interconnection of vast amounts of data. In this way, a high quality and efficient omics technology platform suitable for the study of traditional Chinese medicine will be established, and the reasonable combination of traditional Chinese medicine theory and experience with modern science and the modernization of Chinese medicine will be vigorously promoted.