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目的··:探讨海洛因依赖恒河猴经复方中药康赛德戒断治疗后睾丸结构和功能的恢复情况。方法··:HE染色 ,光镜观察。结果··:在海洛因依赖形成过程中 ,生理盐水对照组(NS组)和康赛德治疗组(CDC组)睾丸均逐渐萎缩变小 ,血清睾酮水平渐进性下降。NS组自然戒断后 ,睾丸体积虽有所恢复 ,但血清睾酮水平持续性下降。自然戒断3个月时 ,睾丸曲细精管全部萎缩 ,成熟精子少或无 ,间质细胞减少或消失 ,间质纤维组织明显增生。在CDC组 ,康赛德治疗后 ,睾丸体积迅速恢复 ,明显大于对照组 (P<0.05) ,血清睾酮水平回升至正常或接近正常(与NS组相比 ,P<0.05)。治疗3个月时 ,睾丸结构基本正常或仅为部分曲细精管萎缩 ,成熟精子较多 ,并可见间质细胞。结论·· :复方中药康赛德能帮助海洛因依赖猴速度更快、程度更佳地恢复睾丸的结构和功能
Objective···: To investigate the recovery of testis structure and function of heroin-dependent rhesus monkeys after compound Connexa withdrawal treatment. Methods ··· HE staining, light microscopy. Results: · During the development of heroin dependence, the testes of the normal saline control group (NS group) and Consider treatment group (CDC group) gradually atrophied and the serum testosterone levels gradually decreased. After natural withdrawal in the NS group, although testicular volume recovered, serum testosterone levels continued to decrease. At 3 months of natural abstinence, the seminiferous tubules in the testis were all shrunken, and there were few or no mature spermatozoa. The number of mesenchymal cells decreased or disappeared, and the interstitial fibrous tissue proliferated. In the CDC group, testicular volume rapidly recovered after Conson’s treatment, which was significantly greater than that in the control group (P<0.05). Serum testosterone levels returned to normal or near normal (P<0.05 compared with NS group). At 3 months of treatment, the testicular structure was almost normal or only part of the seminiferous tubules was atrophied, and more mature spermatozoa were present, with interstitial cells visible. Conclusion···························································································································································································································