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目的探讨食管鳞癌标本中E-cadherin(以下简称E-cad)的表达与其生物学行为的关系。方法采用免疫组化PV-6000法检测E-cad在58例食管鳞癌术后病理标本和20例正常食管组织中的表达。应用SPSS13.0版软件包进行系统分析。结果 E-cad在食管鳞癌中的表达低于正常食管组织,其表达与肿瘤淋巴结转移、浸润深度、临床分期及分化程度密切密切相关。结论 E-cad的异常表达是判断食管鳞癌的生物学行为及患者预后的重要因素。
Objective To investigate the relationship between the expression of E-cadherin (E-cad) and its biological behavior in esophageal squamous cell carcinoma specimens. Methods The expression of E-cad in 58 cases of esophageal squamous cell carcinoma and 20 cases of normal esophageal squamous cell carcinoma were detected by immunohistochemistry PV-6000 method. SPSS13.0 software package for system analysis. Results The expression of E-cad in esophageal squamous cell carcinoma was lower than that in normal esophageal tissue. The expression of E-cad was closely related to lymph node metastasis, depth of invasion, clinical stage and differentiation. Conclusion The abnormal expression of E-cad is an important factor to judge the biological behavior and prognosis of esophageal squamous cell carcinoma.