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本文用新西兰兔和Sprague Dawley大鼠检测了复方甲地孕酮、醋酸甲地孕酮和雌二醇的胚胎毒性和致畸作用。结果表明,复方甲地孕酮低剂量组和高剂量组(即5倍、20倍临床剂量)以及雌二醇低剂量组的兔和大鼠死胎率均为100%,与对照组比较有非常显著性差异(P<0.01)。醋酸甲地孕酮低剂量组和高剂量组的死胎率:兔分别为24.55%和21.43%;大鼠则分别为7.02%和3.42%,与对照组比较无显著性差异(P>0.05)。醋酸甲地孕酮低剂量组兔共有胎仔84只,其中6只畸形胎仔(颅骨缺失或迟化及胸骨缺失或迟化);大鼠114只胎仔未发现畸形。高剂量组兔70只胎仔中有15只为畸形,多见腹裂和骨胳畸形;大鼠无明显畸形胎仔。
In this paper, New Zealand rabbits and Sprague Dawley rats were tested compound megesterone, megestrol acetate and estradiol embryotoxicity and teratogenicity. The results showed that the rate of stillbirths of rabbits and rats in both low-dose and high-dose megestrol groups (ie, 5-fold and 20-fold clinical doses) and the low-dose estradiol group were both 100%, compared with the control group Significant difference (P <0.01). The stillbirth rate of megestrol acetate low dose group and high dose group were 24.55% and 21.43% respectively, and 7.02% and 3.42% respectively in rats. There was no significant difference between the two groups (P> 0.05). A total of 84 fetuses were found in the low-dose megestrol acetate group, including 6 deformed fetuses (missing or late skull and missing or delayed sternum); no abnormalities were found in 114 fetuses. High-dose group of 70 fetuses in 70 fetuses were deformity, more common abdominal malformation and bone deformity; rats without significant deformity fetal.