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用五种实验性心律失常模型比较了α-受体阻滞剂酚妥拉明和β-受体阻滞剂心得安的抗心律失常作用。酚妥拉明2mg/kg、7.5mg/kg、15mg/kg对氯化钡和乌头硷诱发的大白鼠心律失常无对抗作用,15mg/kg酚妥拉明和2mg/kg心得安则对之有明显的对抗作用;这可能与其膜稳定作用有关。酚妥拉明(2mg/kg)和心得安(2mg/kg)对氟仿-肾上腺索诱发的家兔心律失常和氯仿诱发的小白鼠室颤均有明显对抗作用,这可能与心脏的α-或β-受体阻滞有关。
Five experimental arrhythmia models were used to compare the anti-arrhythmic effects of phentolamine and beta-blockers of propranolol. Phentolamine 2mg / kg, 7.5mg / kg, 15mg / kg on barium chloride and aconitine-induced arrhythmia in rats without antagonism, 15mg / kg phentolamine and 2mg / kg of propranolol Obvious antagonistic effect; this may be related to its membrane stability. Phentolamine (2mg / kg) and propranolol (2mg / kg) had significant antagonistic effects on the arrhythmia of rabbit induced by fluoride-adrenal cord and chloroform-induced ventricular fibrillation in rats, which may be related to the α- Or β-receptor block.